Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma

Simple item page
dc.contributor.authorEftekhari, Parivash
dc.contributor.authorHajizadeh, Sohrab
dc.contributor.authorReza Raoufy, Mohammad
dc.contributor.authorReza Masjedi, Mohammad
dc.contributor.authorYang, Ming
dc.contributor.authorHansbro, Nicole
dc.contributor.authorLi, Jing Jing
dc.contributor.authorFoster, Paul S
dc.date.accessioned2015-12-10T23:11:16Z
dc.date.issued2013
dc.date.updated2016-02-24T10:15:43Z
dc.description.abstractOxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in an animal model of steroid resistant acute exacerbation of asthma. Systemically sensitized Balb/C mice were exposed to Ovalbumin aerosol on days 13, 14, 15 and 16, followed by intratracheal lipopolysaccharide (LPS) to induce acute exacerbation. NAC (intraperitoneal, 320 mg/kg 30 min before and 12 hours after each challenge) reduced hyperresponsiveness with/out dexamethasone. LPS application caused neutrophilia in bronchoalveolar lavage fluid (BALF) and eosinophil count was higher than respective control in BALF as well as neutrophils after dexamethasone treatment. NAC significantly decreased neutrophil and eosinophil count in BALF as well as inflammatory cytokines (IL-13 and IL-5).We concluded that addition of NAC to asthma therapy has beneficial preventive effects in an animal model of steroid resistant acute exacerbation of asthma.
dc.identifier.issn1611-2156
dc.identifier.urihttp://hdl.handle.net/1885/63747
dc.publisherUniversitaet Mainz Medical Department
dc.sourceEXCLI Journal
dc.subjectKeywords: acetylcysteine; glucocorticoid; interleukin 13; interleukin 5; steroid; animal experiment; animal model; article; asthma; controlled study; disease exacerbation; disease severity; drug effect; eosinophil count; hormone sensitivity; lung lavage; male; mous Acute exacerbation; Eosinophil; N-acetylcysteine; Neutrophil; Steroid resistant asthma
dc.titlePreventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma
dc.typeJournal article
local.bibliographicCitation.lastpage192
local.bibliographicCitation.startpage184
local.contributor.affiliationEftekhari, Parivash, Tarbiat Modares University
local.contributor.affiliationHajizadeh, Sohrab, Tarbiat Modares University
local.contributor.affiliationReza Raoufy, Mohammad, Tarbiat Modares University
local.contributor.affiliationReza Masjedi, Mohammad, Shahid Beheshti University of Medical Sciences
local.contributor.affiliationYang, Ming, University of Newcastle
local.contributor.affiliationHansbro, Nicole, University of Newcastle
local.contributor.affiliationLi, Jing Jing, University of Newcastle
local.contributor.affiliationFoster, Paul S, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidFoster, Paul S, u8800551
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110107 - Metabolic Medicine
local.identifier.ariespublicationU3488905xPUB843
local.identifier.citationvolume12
local.identifier.scopusID2-s2.0-84875088304
local.identifier.uidSubmittedByU3488905
local.type.statusPublished Version

Downloads

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Eftekhari_Preventive_effect_of_2013.pdf
Size:
513.63 KB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2024 LYRASIS