Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design
| dc.contributor.author | Wijesundara, Danushka Kumara | en_AU |
| dc.contributor.author | Xi, Yang | en_AU |
| dc.contributor.author | Ranasinghe, Charani | en_AU |
| dc.date.accessioned | 2015-12-07T23:50:11Z | |
| dc.date.available | 2015-12-07T23:50:11Z | |
| dc.date.issued | 2014-08-29 | |
| dc.date.updated | 2016-06-14T09:17:16Z | |
| dc.description.abstract | It has been well-established that type I interferons (IFN-Is) have pleiotropic effects and play an early central role in the control of many acute viral infections. However, their pleiotropic effects are not always beneficial to the host and in fact several reports suggest that the induction of IFN-Is exacerbate disease outcomes against some bacterial and chronic viral infections. In this brief review, we probe into this mystery and try to develop answers based on past and recent studies evaluating the roles of IFN-Is in infection and immunity as this is vital for developing effective IFN-Is based therapeutics and vaccines. We also discuss the biological roles of an emerging IFN-I, namely IFN-ε, and discuss its potential use as a mucosal therapeutic and/or vaccine adjuvant. Overall, we anticipate the discussions generated in this review will provide new insights for better exploiting the biological functions of IFN-Is in developing efficacious therapeutics and vaccines in the future. | |
| dc.description.sponsorship | This work was supported by Australian National Health and Medical Research Council project grant award 525431 (Charani Ranasinghe) and ACH2 EOI grants (Charani Ranasinghe). | en_AU |
| dc.identifier.issn | 1664-3224 | en_AU |
| dc.identifier.uri | http://hdl.handle.net/1885/28544 | |
| dc.publisher | Frontiers Research Foundation | |
| dc.relation | http://purl.org/au-research/grants/nhmrc/525431 | |
| dc.rights | © 2014 Wijesundara, Xi and Ranasinghe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
| dc.source | Frontiers in Immunology | |
| dc.source.uri | http://journal.frontiersin.org/article/10.3389/fimmu.2014.00412/full | en_AU |
| dc.subject | ifn-ε | |
| dc.subject | human immunodeficiency virus | |
| dc.subject | interferon immunity | |
| dc.subject | type i interferons | |
| dc.subject | vaccine adjuvants | |
| dc.title | Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design | |
| dc.type | Journal article | |
| local.bibliographicCitation.issue | August | |
| local.bibliographicCitation.lastpage | 7 | |
| local.bibliographicCitation.startpage | 412 | en_AU |
| local.contributor.affiliation | Wijesundara, Danushka, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, Immunology and Infectious Disease, The Australian National University | en_AU |
| local.contributor.affiliation | Xi, Yang, The University of Queensland, Australia | en_AU |
| local.contributor.affiliation | Ranasinghe, Charani, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, Immunology and Infectious Disease, The Australian National University | en_AU |
| local.contributor.authoruid | Wijesundara, Danushka, u4092312 | en_AU |
| local.description.notes | Imported from ARIES | en_AU |
| local.identifier.absfor | 110799 | en_AU |
| local.identifier.ariespublication | u6800332xPUB236 | en_AU |
| local.identifier.citationvolume | 5 | en_AU |
| local.identifier.doi | 10.3389/fimmu.2014.00412 | en_AU |
| local.identifier.essn | 1664-3224 | en_AU |
| local.identifier.scopusID | 2-s2.0-84918829601 | |
| local.publisher.url | http://journal.frontiersin.org/ | en_AU |
| local.type.status | Published Version | en_AU |