Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

Date

2009

Authors

Ono, R.
Kumagai, H.
Nakajima, H.
Hishiya, A.
Taki, T.
Horikawa, Keisuke
Takatsu, Kiyoshi
Satoh, T.
Hayashi, Y.
Kitamura, T.

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

Mixed-lineage-leukemia (MLL) fusion oncogenes are closely involved in infant acute leukemia, which is frequently accompanied by mutations or overexpression of FMS-like receptor tyrosine kinase 3 (FLT3). Earlier studies have shown that MLL fusion proteins

Description

Keywords

Keywords: homeodomain protein; mixed lineage leukemia protein; oncoprotein; Raf protein; Ras protein; transcription factor HoxA9; acute disease; animal; article; gene expression regulation; genetics; leukemia; metabolism; mouse; physiology; signal transduction; Acu leukemogenesis; MAP kinase; MLL; Ras

Citation

Source

Leukemia

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/leu.2009.177

Restricted until

2037-12-31