A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation
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Authors
Ahmed, Jehangir
Ali, Radiya
Warr, Nicholas
Wilson, Heather
Bellchambers, Helen
Barratt, Kristen
Thompson, Amelia
Arkell, Ruth
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The Company of Biologists Ltd
Abstract
The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-co
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Disease Models and Mechanisms
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Open Access