Size and sulfation are critical for the effect of heparin on APP processing and Aβ production
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Cui, Hao
Hung, Amos C
Freeman, Craig
Narkowicz, Christian
Jacobsen, Glenn A.
Small, David H
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Blackwell Publishing Ltd
Abstract
Alzheimer's disease is associated with abnormal accumulation of Aβ, which is produced from the β-amyloid precursor protein (APP) by the β-site APP-cleaving enzyme (BACE1) and Î-secretase. Our previous studies showed that heparin can decrease APP proce
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Journal of Neurochemistry
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2037-12-31
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