Rapid screening of cellular stress responses in recombinant Pichia pastoris strains using metabolite profiling

Date

2017

Authors

Tredwell, Greg
Aw, Rochelle
Edwards-Jones, Bryn
Leak, David J
Bundy, Jacob G

Journal Title

Journal ISSN

Volume Title

Publisher

Springer Verlag

Abstract

Heterologous protein production in the yeast Pichia pastoris can be limited by biological responses to high expression levels; the unfolded protein response (UPR) is a key determinant of the success of protein production in this organism. Here, we used untargeted NMR metabolic profiling (metabolomics) of a number of different recombinant strains, carried out in a miniaturized format suitable for screening-level experiments. We identified a number of metabolites (from both cell extracts and supernatants) which correlated well with UPR-relevant gene transcripts, and so could be potential biomarkers for future high-throughput screening of large numbers of P. pastoris clones.

Description

Keywords

Metabolic footprinting, Unfolded protein response, Clonal variation, Bioprocessing, Recombinant protein

Citation

Source

Journal of Industrial Microbiology and Biotechnology

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

Creative Commons Attribution 4.0 International License

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