Cytokines in innate and adaptive immunity

Date

2000

Authors

Banyer, Joanne
Hamilton, Nicholas H R
Ramshaw, Ian
Ramsay, R

Journal Title

Journal ISSN

Volume Title

Publisher

Munksgaard International Publishers

Abstract

Cytokines and chemokines are hormone-like messengers which act to regulate the development and expression of the broad array of immune responses that are mounted against a variety of pathogens. As such, they are critical determinants of the types of cells which will regulate and participate in innate and adaptive immune responses, they may act both in highly localised environments but also in a systemic manner, and they may, themselves, directly mediate antimicrobial effector activities. In this article, we will outline current concepts of the activities of cytokines and chemokines in the immune response and discuss the various cell types, including dendritic cells and other antigen-presenting cells, T cells and B cells, which both produce and respond to these potent regulatory molecules.

Description

Keywords

Keywords: chemokine; cytokine; gamma interferon; glycoprotein gp 39; interleukin 12; interleukin 1alpha; interleukin 2; interleukin 4; interleukin 5; interleukin 6; interleukin 7; tumor necrosis factor alpha; adaptation; antimicrobial activity; B lymphocyte; cytoki Adaptive immunity; Chemokine; Cytokine; Dendritic cells; Innate immunity

Citation

Source

Reviews in Immunogenetics

Type

Journal article

Book Title

Entity type

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