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Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim

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Date

2004

Authors

Liston, Adrian
Lesage, Sylvie
Gray, Derek
O'Reilly, Lorraine A
Strasser, Andreas
Fahrer, Aude
Boyd, Richard L
Wilson, Judith
Baxter, Alan G
Gallo, Elena

Journal Title

Journal ISSN

Volume Title

Publisher

Cell Press

Abstract

The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and

Description

Keywords

Keywords: autoantigen; BIM protein; calcineurin; CD4 antigen; CD8 antigen; gene product; interleukin 2 receptor; mitogen activated protein kinase 1; animal cell; animal experiment; animal tissue; antigen expression; apoptosis; article; autoimmunity; controlled stud

Citation

URI

http://hdl.handle.net/1885/85984

Collections

ANU Research Publications

Source

Immunity

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.immuni.2004.10.014

Restricted until

2037-12-31

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Description
01_Liston_Generalized_resistance_to_2004.pdf (760.43 KB)

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