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Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation

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Date

2008

Authors

Larter, Claire
Yeh, Matthew
Cheng, Jenny
Williams, Jacqueline
Brown, Sandie
dela Pena, Aileen
Bell-Anderson, Kim S
Farrell, Geoffrey

Journal Title

Journal ISSN

Volume Title

Publisher

Blackwell Publishing Ltd

Abstract

Background and Aim: Non-alcoholic fatty liver disease is the result of an imbalance in hepatic lipid partitioning that favors fatty acid synthesis and storage over fatty acid oxidation and triglyceride secretion. The progressive, inflammatory disorder of

Description

Keywords

Keywords: fish oil; ligand; lipid peroxide; methionine; monounsaturated fatty acid; olive oil; omega 3 fatty acid; peroxisome proliferator activated receptor alpha; animal experiment; animal model; article; controlled study; diet supplementation; fatty acid oxidati Hepatic lipid synthesis; Lipid peroxidation; Methionine and choline deficient diet; Non-alcoholic fatty liver disease; Peroxisome proliferator-activated receptor; Polyunsaturated fatty acids

Citation

URI

http://hdl.handle.net/1885/57426

Collections

ANU Research Publications

Source

Journal of Gastroenterology and Hepatology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/j.1440-1746.2007.05157.x

Restricted until

2037-12-31

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