Intrinsic Defect in T Cell Production of Interleukin (1L)-13 in the Absence of Both IL-5 and Eotaxin Precludes the Development of Eosinophilia and Airways Hyperreactivity in Experimental Asthma

Mattes, Joerg; Yang, Ming; Mahalingam, Surendran; Kuehr, Joachim; Webb, Dianne; Simson, Ljubov; Hogan, Simon; Koskinen, Aulikki; Mckenzie, Andrew N; Dent, Lindsay; Rothenberg, Marc E; Matthaei, Klaus; Young, Ian; Foster, Paul S

Intrinsic Defect in T Cell Production of Interleukin (1L)-13 in the Absence of Both IL-5 and Eotaxin Precludes the Development of Eosinophilia and Airways Hyperreactivity in Experimental Asthma

Date

2002

Authors

Mattes, Joerg

Yang, Ming

Mahalingam, Surendran

Kuehr, Joachim

Webb, Dianne

Simson, Ljubov

Hogan, Simon

Koskinen, Aulikki

Mckenzie, Andrew N

Dent, Lindsay

Publisher

Rockefeller University Press

Abstract

Interleukin (IL)-5 and IL-13 are thought to play key roles in the pathogenesis of asthma. Although both cytokines use eotaxin to regulate eosinophilia, IL-13 is thought to operate a separate pathway to IL-5 to induce airways hyperreactivivy, (AHR) in the