Monotreme sex chromosomes: implications for the evolution of amniote sex chromosomes

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dc.contributor.authorWaters, Paul
dc.contributor.authorGraves, Jennifer
dc.date.accessioned2015-12-10T23:04:36Z
dc.date.available2015-12-10T23:04:36Z
dc.date.issued2009
dc.date.updated2016-02-24T11:53:22Z
dc.description.abstractIn vertebrates, a highly conserved pathway of genetic events controls male and female development, to the extent that many genes involved in human sex determination are also involved in fish sex determination. Surprisingly, the master switch to this pathway, which intuitively could be considered the most critical step, is inconsistent between vertebrate taxa. Interspersed in the vertebrate tree there are species that determine sex by environmental cues such as the temperature at which eggs are incubated, and then there are genetic sex-determination systems, with male heterogametic species (XY systems) and female heterogametic species (ZW systems), some of which have heteromorphic, and others homomorphic, sex chromosomes. This plasticity of sex-determining switches in vertebrates has made tracking the events of sex chromosome evolution in amniotes a daunting task, but comparative gene mapping is beginning to reveal some striking similarities across even distant taxa. In particular, the recent completion of the platypus genome sequence has completely changed our understanding of when the therian mammal X and Y chromosomes first arose (they are up to 150million years younger than previously thought) and has also revealed the unexpected insight that sex determination of the amniote ancestor might have been controlled by a bird-like ZW system.
dc.identifier.issn1031-3613
dc.identifier.urihttp://hdl.handle.net/1885/62436
dc.publisherCSLI Publications
dc.sourceReproduction, Fertility and Development
dc.subjectKeywords: bird; evolution; gene mapping; genetic regulation; monotremate; nonhuman; orthology; placental mammals; platypus; review; sex chromosome; sex determination; snake; vertebrate; X chromosome; Y chromosome; Amnion; Animals; Evolution, Molecular; Female; Geno
dc.titleMonotreme sex chromosomes: implications for the evolution of amniote sex chromosomes
dc.typeJournal article
local.bibliographicCitation.lastpage951
local.bibliographicCitation.startpage943
local.contributor.affiliationWaters, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGraves, Jennifer, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4025262@anu.edu.au
local.contributor.authoruidWaters, Paul, u4025262
local.contributor.authoruidGraves, Jennifer, u4021869
local.description.notesImported from ARIES
local.identifier.absfor060408 - Genomics
local.identifier.ariespublicationu9204316xPUB698
local.identifier.citationvolume21
local.identifier.doi10.1071/RD09250
local.identifier.scopusID2-s2.0-71049178247
local.identifier.thomsonID000271247100004
local.identifier.uidSubmittedByu9204316
local.type.statusPublished Version

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