Mechanisms of accelerated immune-mediated diabetes resulting from islet β cell expression of a Fas ligand transgene
Date
2003
Authors
Silva, Diego
Petrovsky, Nikolai
Socha, L
Slattery, Robyn
Gatenby, Paul
Charlton, Brett
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Volume Title
Publisher
American Association of Immunologists
Abstract
Nonobese diabetic (NOD) mice transgenic for Fas ligand (FasL) on islet β cells (HIPFasL mice) exhibit an accelerated diabetes distinct from the normal autoimmune diabetes of NOD mice. This study was undertaken to define the mechanism underlying accelerat
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Keywords
Keywords: Fas antigen; FAS ligand; animal cell; animal experiment; animal model; antigen expression; article; controlled study; diabetes mellitus; histopathology; immunopathogenesis; male; mouse; nonhuman; pancreas islet beta cell; priority journal; transgenic mous
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Source
Journal of Immunology
Type
Journal article
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2037-12-31
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