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Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives

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Date

2018

Authors

Rehmani, Muhammad
Chang, Ee
Draffan, Alistair
Willis, Anthony
Carr, Paul D
Banwell, Martin

Journal Title

Journal ISSN

Volume Title

Publisher

CSIRO Publishing

Abstract

A range of structural variations on the tricarbocyclic core 2 of the anti-bacterial agent platencin 1, including those represented by compounds 14, 15, and 27, have been prepared and certain of these elaborated, through substrate-controlled enolate alkylation reactions, to analogues of the natural product. Preliminary biological evaluation of these analogues revealed that they are only weakly active anti-infective agents.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/164795

Collections

ANU Research Publications

Source

Australian Journal of Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1071/CH18145

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Chemoenzymatic Syntheses of Some Analogues AAM.pdf (598.45 KB)

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