A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux
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Authors
Krokowski, Dawid
Han, Jaeseok
Saikia, Mridusmita
Majumder, Mithu
Yuan, Celvie L
Guan, Bo-Jhih
Bevilacqua, Elena
Bussolati, Ovidio
Bröer, Stefan
Arvan, Peter
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American Society for Biochemistry and Molecular Biology
Abstract
BACKGROUND: Protein synthesis control is important for β-cell fate during ER stress.
RESULTS: Increased protein synthesis during chronic ER stress in β-cells involves the transcriptional induction of an amino acid
transporter network. CONCLUSION: Increased amino acid uptake in β-cells during ER stress promotes apoptosis. SIGNIFICANCE: Induced expression of a network of amino acid transporters in islets can contribute to chronic ER stress-induced diabetes.
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Keywords
activating, transcription, factor, 4, metabolism, amino, acid, transport, systems, genetics, aminoacyl, tRNA, synthetases, animals, apoptosis, cell, survival, diabetes, mellitus, type, 2, pathology, endoplasmic, reticulum, stress, eukaryotic, initiation, HEK293, humans, insulin, physiology, male, mice, inbred, C57BL, phosphorylation, protein, processing, post, translational, RNA
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Journal of Biological Chemistry 288. 24 (2013): 17202-17213