Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system

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dc.contributor.authorSpalding, Kirsty
dc.contributor.authorTan, M
dc.contributor.authorHendry, Ian
dc.contributor.authorHartunian, A
dc.date.accessioned2015-12-13T22:17:43Z
dc.date.issued2002
dc.date.updated2015-12-11T07:36:04Z
dc.description.abstractDuring development the viability of immature neurons may depend upon retrograde, anterograde, or paracrine trophic support. Using125I-labeled peptides we show that there is substantial and rapid anterograde transport of brain-derived neurotrophic factor (BDNF) and, to a lesser extent, neurotrophin-4/5 (NT-4/5) to central visual target areas in the neonatal rat brain. Six hours after unilateral intraocular injection, all retinorecipient regions in the thalamus and midbrain are heavily labeled. Intraocular application of physiologically relevant doses of neurotrophin has a marked effect on cells in the developing superior colliculus (SC): 24 h postinjection of BDNF or NT-4/5, the number of pyknotic profiles in the contralateral superficial SC significantly decreases, while total cell numbers increase relative to ipsilateral SC. This increase is primarily associated with neurons. The data support the hypothesis that BDNF and NT-4/5 are anterograde survival factors for postsynaptic cells in the developing rat SC.
dc.identifier.issn1044-7431
dc.identifier.urihttp://hdl.handle.net/1885/71289
dc.publisherAcademic Press
dc.sourceMolecular and Cellular Neuroscience
dc.subjectKeywords: brain derived neurotrophic factor; iodine 125; neurotrophin 4; animal cell; article; autoradiography; bioassay; cell count; cell death; fluorescence; immunohistochemistry; nerve cell; nonhuman; priority journal; rat; retina ganglion cell; stereology; supe
dc.titleAnterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage500
local.bibliographicCitation.startpage485
local.contributor.affiliationSpalding, Kirsty, University of Western Australia
local.contributor.affiliationTan, M, University of Hong Kong
local.contributor.affiliationHendry, Ian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHartunian, A, California Institute of Technology
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidHendry, Ian, u7600265
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110906 - Sensory Systems
local.identifier.ariespublicationMigratedxPub2647
local.identifier.citationvolume19
local.identifier.doi10.1006/mcne.2001.1097
local.identifier.scopusID2-s2.0-0036246450
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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