Vitamin C supplementation in kidney failure: Effect on uraemic symptoms

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dc.contributor.authorSinger, Richard
dc.date.accessioned2015-12-10T23:24:19Z
dc.date.issued2011
dc.date.updated2016-02-24T08:13:36Z
dc.description.abstractBackground. Vitamin C (ascorbate) deficiency and symptoms consistent with deficiency (fatigue, myalgia, dyspnoea, gingivitis, cardiovascular instability and depression) are common in patients with renal failure. This study aimed to determine if supplementation with ascorbate in patients with severe renal failure improved symptoms or cardiovascular stability, or was associated with adverse effects.Methods. The study was a 3-month, double-blind, randomized trial of ascorbic acid 250 mg or matching placebo given thrice weekly. Subjects were clinically stable and either received conventional dialysis or had an estimated glomerular filtration rate of <20 mL/min. Symptoms were measured using the Kidney Dialysis Quality of Life-Short Form (KDQOL-SF™) symptom subscale, and the study was 80% powered to detect a change of 10 in the KDQOL-SF™.Results. Ninety-nine subjects were randomized, and ascorbate deficiency was present in 40% at baseline. Mean symptom scores at follow-up were similar in the two groups (P-value = 0.19). There was a trend to slightly worse nausea scores in the ascorbate group after controlling for the level of baseline nausea (P = 0.09), and there was no impact on cardiovascular stability. Compliance appeared adequate at 91%, and deficiency was corrected in most (85%) of the subjects in the active treatment group.Conclusions. This study indicates that ascorbate supplementation does not improve symptoms or cardiovascular stability in those with severe renal impairment, but is associated with a trend towards worse nausea.
dc.identifier.issn0931-0509
dc.identifier.urihttp://hdl.handle.net/1885/67130
dc.publisherOxford University Press
dc.sourceNephrology Dialysis Transplantation
dc.subjectKeywords: ascorbic acid; placebo; aged; article; ascorbic acid deficiency; cardiovascular effect; dialysis; double blind procedure; drug efficacy; drug safety; female; follow up; glomerulus filtration rate; human; kidney failure; major clinical study; male; nausea; ascorbic acid; hypotension; kidney failure; quality of life; renal dialysis
dc.titleVitamin C supplementation in kidney failure: Effect on uraemic symptoms
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage620
local.bibliographicCitation.startpage614
local.contributor.affiliationSinger, Richard, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidSinger, Richard, a304487
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110312 - Nephrology and Urology
local.identifier.absfor111102 - Dietetics and Nutrigenomics
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
local.identifier.ariespublicationf2965xPUB1403
local.identifier.citationvolume26
local.identifier.doi10.1093/ndt/gfq412
local.identifier.scopusID2-s2.0-79551483659
local.identifier.uidSubmittedByf2965
local.type.statusPublished Version

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