The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes

Date

2004

Authors

Blanden, Robert
Franklin, Andrew
Steele, Edward J

Journal Title

Journal ISSN

Volume Title

Publisher

Blackwell Publishing Ltd

Abstract

Available evidence about the mechanisms and distribution of somatic hypermutation (SHM) of rearranged immunoglobulin (IgV) genes is reviewed with particular emphasis on the 5′ boundary. In heavy (H) chain genes, the 5′ boundary of SHM is the transcrip

Description

Keywords

Keywords: complementary DNA; DNA polymerase; messenger RNA; RNA polymerase II; small nuclear RNA; transcription factor; alpha chain; DNA replication; DNA sequence; exon; gene expression; gene locus; immunoglobulin gene; immunoglobulin variable region; intron; nonhu 5' boundary of somatic hypermutation; DNA polymerase ?; Pre-mRNA processing; Rearranged immunoglobulin genes; Reverse transcription

Citation

URI

http://hdl.handle.net/1885/78289

Collections

ANU Research Publications

Source

Immunology and Cell Biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1046/j.0818-9641.2004.01226.x

Restricted until

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