Vascular changes in fetal growth restriction: clinical relevance and future therapeutics

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dc.contributor.authorSehgal, Arvind
dc.contributor.authorMurthi, Padma
dc.contributor.authorDahlstrom, Jane
dc.date.accessioned2022-06-09T00:25:15Z
dc.date.issued2019
dc.date.updated2021-01-17T07:20:44Z
dc.description.abstractFetal growth restriction (FGR) affects about 5–10% pregnancies and is associated with poorer outcomes in the perinatal period. Additionally, long standing epidemiological data support its association with chronic diseases such as hypertension and diabetes. Cardiac and vascular adaptations in response to chronic hypoxemia due to utero-placental insufficiency are hallmarks of fetal adaptations. Investigators have attempted to identify these changes in the placenta at the microscopic and molecular level. The ex vivo dual perfusion model of the placenta enables the study of placental haemodynamics in growth-restricted pregnancies. Persistent arterial abnormalities (thickness and stiffness) noted on vascular ultrasound during fetal life through to the young-adult age group for those affected by FGR, seem to be a plausible link between in utero events and chronic circulatory diseases. Using these, this review reflects current thought on vascular maladaptive changes in the FGR cohorts and the role in investigating current and future therapeuticsen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0743-8346en_AU
dc.identifier.urihttp://hdl.handle.net/1885/267242
dc.language.isoen_AUen_AU
dc.publisherNature Publishing Groupen_AU
dc.rights© 2018 The authorsen_AU
dc.sourceJournal of Perinatologyen_AU
dc.titleVascular changes in fetal growth restriction: clinical relevance and future therapeuticsen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue3en_AU
local.bibliographicCitation.lastpage374en_AU
local.bibliographicCitation.startpage366en_AU
local.contributor.affiliationSehgal, Arvind, Monash Universityen_AU
local.contributor.affiliationMurthi, Padma, University of Melbourneen_AU
local.contributor.affiliationDahlstrom, Jane, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu3725583@anu.edu.auen_AU
local.contributor.authoruidDahlstrom, Jane, u3725583en_AU
local.description.embargo2099-12-01
local.description.notesImported from ARIESen_AU
local.identifier.absfor110316 - Pathologyen_AU
local.identifier.absseo920114 - Reproductive System and Disordersen_AU
local.identifier.ariespublicationu5786633xPUB538en_AU
local.identifier.citationvolume39en_AU
local.identifier.doi10.1038/s41372-018-0287-4en_AU
local.identifier.scopusID2-s2.0-85058005506
local.identifier.uidSubmittedByu5786633en_AU
local.publisher.urlhttps://www.nature.com/en_AU
local.type.statusPublished Versionen_AU

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