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Physico-chemical modelling of target depletion during hybridization on oligonulceotide microarrays

Date

2010

Authors

Burden, Conrad
Binder, Hans

Journal Title

Journal ISSN

Volume Title

Publisher

Institute of Physics Publishing

Abstract

The effect of target molecule depletion from the supernatant solution is incorporated into a physico-chemical model of hybridization on oligonucleotide microarrays. Two possible regimes are identified: local depletion, in which depletion by a given probe

Description

Keywords

Keywords: article; chemical model; DNA microarray; methodology; nucleic acid hybridization; physical chemistry; Models, Chemical; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Physicochemical Phenomena

Citation

Source

Physical Biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1088/1478-3975/7/1/016004

Restricted until

2037-12-31