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TNF and leptin tell essentially the same story in Alzheimer's disease

Date

Authors

Clark, Ian A

Alleva, Lisa

Vissel, Bryce

Publisher

IOS Press

Abstract

Both tumor necrosis factor (TNF) and leptin are, independently, under investigation as the central mechanism for Alzheimer's disease. The wider literature provides every indication that both mediators are part of the same pathways thought to cause functional loss in this condition. This association, which has not been specifically addressed in the Alzheimer's disease literature, may be a useful link to expedite future study into the pathogenesis of this condition.

Keywords

Keywords: etanercept; infliximab; leptin; pentetrazole; tumor necrosis factor; tumor necrosis factor inhibitor; Alzheimer disease; article; cerebrospinal fluid; gene mutation; in vitro study; in vivo study; nervous system development; nonhuman; pathogenesis; priori Alzheimer's disease; inflammation; leptin; tumor necrosis factor

URI

http://hdl.handle.net/1885/38183

Collections

ANU Research Publications

Source

Journal of Alzheimer's Disease

Type

Journal article

DOI

10.3233/JAD-2011-110266

Restricted until

2037-12-31

Downloads

File

Description

01_Clark_TNF_and_leptin_tell_2011.pdf (4.98 MB)