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Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic plasmodium falciparum parasites

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Date

2013

Authors

Niemand, J
Burger, Pieter
Verlinden, Bianca K
Reader, Janette
Joubert, Annie M
Kaiser, Annette
Louw, A I
Kirk, Kiaran
Phanstiel IV, Otto
Birkholtz, L

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to ±Mrange. The compounds are taken up into the intraerythrocyt

Description

Keywords

Keywords: anthracene; anthracene polyamine conjugate; antimalarial agent; polyamine; putrescine; unclassified drug; animal cell; antimalarial activity; article; cell proliferation; drug absorption; drug distribution; drug excretion; drug metabolism; human; human ce

Citation

URI

http://hdl.handle.net/1885/72743

Collections

ANU Research Publications

Source

Antimicrobial Agents and Chemotherapy

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1128/AAC.00106-13

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