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The F 1 -ATPase inhibitor Inh1 (IF1) affects suppression of mtDNA loss-lethality in Kluyveromyces lactis

Date

Authors

Clark-Walker, George

Publisher

Blackwell Publishing Ltd

Abstract

Loss of mtDNA by the petite-negative yeast Kluyveromyces lactis is lethal (ρo-lethality). However, mutations in the α, β and γ subunits of F1-ATPase can suppress lethality by increasing intramitochondrial hydrolysis of ATP. Increased hydrolysis of ATP

Keywords

Keywords: adenosine triphosphate; ethidium bromide; mitochondrial DNA; proton transporting adenosine triphosphate synthase; proton transporting adenosine triphosphate synthase inhibitor; ATPase inhibitory protein; enzyme inhibitor; protein; proton transporting aden Disruption of INH1; Interaction of Inh1 with F1; Kinetic parameters of F1-ATPase; Suppression of ?o-lethality

URI

http://hdl.handle.net/1885/54356

Collections

ANU Research Publications

Source

FEMS Yeast Research

Type

Journal article

DOI

10.1111/j.1567-1364.2006.00201.x

Restricted until

2037-12-31

Downloads

File

Description

01_Clark-Walker_The_F_1_-ATPase_inhibitor_Inh1_2007.pdf (1.38 MB)