CEREBRAL ATROPHY IN MILD COGNITIVE IMPAIRMENT A SYSTEMATIC REVIEW WITH META ANALYSIS

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dc.contributor.authorCherbuin, Nicolas
dc.contributor.authorShaw, Marnie
dc.date.accessioned2018-11-29T22:57:26Z
dc.date.available2018-11-29T22:57:26Z
dc.date.issued2015
dc.date.updated2018-11-29T08:17:52Z
dc.description.abstractIntroduction: Although mild cognitive impairment (MCI) diagnosis is mainly based on cognitive assessment, reliable estimates of structural changes in specific brain regions, that could be contrasted against normal brain aging and inform diagnosis, are lacking. This study aimed to systematically review the literature reporting on MCI-related brain changes. Methods: The MEDLINE database was searched for studies investigating longitudinal structural changes in MCI. Studies with compatible data were included in the meta-analyses. A qualitative review was conducted for studies excluded from meta-analyses. Results: The analyses revealed a 2.2-fold higher volume loss in the hippocampus, 1.8-fold in the whole brain, and 1.5-fold in the entorhinal cortex in MCI participants. Conclusion: Although the medial temporal lobe is likely to be more vulnerable to MCI pathology, atrophy in this brain area represents a relatively small proportion of whole brain loss, suggesting that future investigations are needed to identify the source of unaccounted volume loss in MCI.
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2352-8729
dc.identifier.urihttp://hdl.handle.net/1885/153870
dc.publisherElsevier B.V
dc.sourceAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
dc.titleCEREBRAL ATROPHY IN MILD COGNITIVE IMPAIRMENT A SYSTEMATIC REVIEW WITH META ANALYSIS
dc.typeJournal article
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage504
local.bibliographicCitation.startpage487
local.contributor.affiliationCherbuin, Nicolas, College of Health and Medicine, ANU
local.contributor.affiliationShaw, Marnie, College of Health and Medicine, ANU
local.contributor.authoremailu3184049@anu.edu.au
local.contributor.authoruidCherbuin, Nicolas, u3184049
local.contributor.authoruidShaw, Marnie, u3627775
local.description.notesImported from ARIES
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.absfor110900 - NEUROSCIENCES
local.identifier.absfor170100 - PSYCHOLOGY
local.identifier.ariespublicationU3488905xPUB8551
local.identifier.citationvolume1
local.identifier.doi10.1016/j.dadm.2015.11.002
local.identifier.scopusID2-s2.0-84954124863
local.identifier.thomsonIDMEDLINE:27239527
local.identifier.uidSubmittedByU3488905
local.type.statusPublished Version

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