Effects of cerebrovascular risk factors on gray matter volume in adults aged 60-64 years: A voxel-based morphometric study

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dc.contributor.authorChen, Xiaohua
dc.contributor.authorWen, Wei
dc.contributor.authorSachdev, Perminder Singh
dc.contributor.authorAnstey, Kaarin
dc.date.accessioned2015-12-07T22:53:44Z
dc.date.issued2006
dc.date.updated2015-12-07T12:42:21Z
dc.description.abstractThe effect of putative cerebrovascular risk factors on gray matter volume in a community-dwelling, non-demented 60- to 64-year-old cohort was investigated. Cranial T1-weighted MRI scans were obtained in 337 adults and voxel-based morphometric analyses were applied to detect regional gray matter volume differences related to hypertension, diabetes, smoking, and hyperlipidemia in men and women, respectively. Hypertension-related gray matter volume reduction was found in right superior, bilateral medial frontal, left superior temporal and left precentral gyri in men. No regional differences in gray matter related to hypertension were seen in women. Conversely, female but not male smokers had more gray matter volume in right fusiform gyrus and right temporal subgyral gray matter. No differences were observed in gray matter volume in association with diabetes or hyperlipidemia for men or women. Our results suggest that there are different patterns of regional effects in gray matter volume in relation to different cerebrovascular risk factors, and sex differences for the same risk factors.
dc.identifier.issn0925-4927
dc.identifier.urihttp://hdl.handle.net/1885/27860
dc.publisherElsevier
dc.sourcePsychiatry Research: Neuroimaging
dc.subjectKeywords: adult; aged; article; brain blood vessel; brain size; cingulate gyrus; cohort analysis; community; diabetes mellitus; disease association; female; frontal cortex; gray matter; human; hyperlipidemia; hypertension; major clinical study; male; morphometrics; Brain; Hypertension; Magnetic resonance imaging; Smoking; Voxel-based morphometry
dc.titleEffects of cerebrovascular risk factors on gray matter volume in adults aged 60-64 years: A voxel-based morphometric study
dc.typeJournal article
local.bibliographicCitation.issue2-3
local.bibliographicCitation.lastpage114
local.bibliographicCitation.startpage105
local.contributor.affiliationChen, Xiaohua, University of New South Wales (& Prince of Wales Hosp)
local.contributor.affiliationWen, Wei, University of New South Wales (Prince of Wales Hospital)
local.contributor.affiliationAnstey, Kaarin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSachdev, Perminder Singh, University of New South Wales (Prince of Wales Hospital)
local.contributor.authoremailu4038535@anu.edu.au
local.contributor.authoruidAnstey, Kaarin, u4038535
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111714 - Mental Health
local.identifier.absfor110903 - Central Nervous System
local.identifier.absseo920410 - Mental Health
local.identifier.ariespublicationU4146231xPUB54
local.identifier.citationvolume147
local.identifier.doi10.1016/j.pscychresns.2006.01.009
local.identifier.scopusID2-s2.0-33748712631
local.identifier.uidSubmittedByU4146231
local.type.statusPublished Version

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