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Analogues of SB-203207 as Inhibitors of tRNA Synthetases

Date

2000

Authors

Banwell, Martin
Crasto, Curtis
Easton, Christopher
Forrest, Andrew
Karoli, Tomislav
March, Darren
Mensah, Lucy
Nairn, Michael
O'Hanlon, Peter
Oldham, Mark

Journal Title

Journal ISSN

Volume Title

Publisher

Pergamon-Elsevier Ltd

Abstract

SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and

Description

Keywords

Keywords: altemicidin; amino acid transfer RNA ligase; antiinfective agent; sb 203207; tRNA synthetase inhibitor; unclassified drug; antibacterial activity; article; drug mechanism; drug potency; drug synthesis; enzyme inhibition; nonhuman; Staphylococcus aureus; s

Citation

Source

Bioorganic and Medicinal Chemistry Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/S0960-894X(00)00456-X

Restricted until

2037-12-31