Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes

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dc.contributor.authorHilder, Tamsyn
dc.contributor.authorHill, James M
dc.date.accessioned2015-12-07T22:46:49Z
dc.date.issued2007
dc.date.updated2015-12-07T11:46:28Z
dc.description.abstractThe proposed use of nanocapsules in drug delivery systems promises many advantages over current procedures. The major advantage is the potential for patients to have significantly reduced side effects from taking the drug, especially for highly toxic drugs such as those used for cancer treatments. Nanotubes have been suggested as one such carrier to deliver a drug to a specific site, giving rise to the notion of the 'magic bullet'. The aim of this paper is to determine whether a particular nanotube would accept a particular drug, and to determine the radius of the nanotube that provides the maximum uptake of the drug molecule. In particular, this paper looks at the drug cisplatin, a platinum based anticancer drug widely used in the treatment of tumours. Three orientations of cisplatin, a polar molecule, are investigated as it enters the nanotube. It is shown that, for all three orientations of cisplatin to be accepted into the carbon nanotube, the minimum radius must be at least 4.785 Å, which is slightly smaller than a (9, 5) nanotube and that the maximum suction energy occurs when the carbon nanotube radius is approximately 5.3 Å, which is approximately equivalent to a (11, 4) nanotube. This paper presents for the first time a calculation of this nature, and although the model represents only a first approximation, it constitutes a necessary preliminary calculation which might provide medical scientists with some overall guidelines.
dc.identifier.issn0957-4484
dc.identifier.urihttp://hdl.handle.net/1885/25937
dc.publisherInstitute of Physics Publishing
dc.sourceNanotechnology
dc.subjectKeywords: Carbon nanotubes; Drug delivery; Encapsulation; Medical nanotechnology; Oncology; Patient monitoring; Tumors; Drug cisplatin; Medical scientists; Suction energy; Toxic drugs; Drug products; antineoplastic agent; carbon nanotube; cisplatin; platinum; artic
dc.titleModelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes
dc.typeJournal article
local.bibliographicCitation.issue27
local.bibliographicCitation.lastpage275713
local.bibliographicCitation.startpage275704
local.contributor.affiliationHilder, Tamsyn, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHill, James M, University of Wollongong
local.contributor.authoremailu4594267@anu.edu.au
local.contributor.authoruidHilder, Tamsyn, u4594267
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor100700 - NANOTECHNOLOGY
local.identifier.ariespublicationu4692404xPUB41
local.identifier.citationvolume18
local.identifier.doi10.1088/0957-4484/18/27/275704
local.identifier.scopusID2-s2.0-34250707215
local.identifier.uidSubmittedByu4692404
local.type.statusPublished Version

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