Bone loss markers in the earliest Pacific Islanders

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dc.contributor.authorMiszkiewicz, Justyna
dc.contributor.authorValentin, Frederique
dc.contributor.authorVrahnas, Christina
dc.contributor.authorSims, Natalie
dc.contributor.authorVongsvivut, Jitraporn
dc.contributor.authorTobin, Mark
dc.contributor.authorClark, Geoffrey
dc.date.accessioned2023-07-25T23:26:32Z
dc.date.available2023-07-25T23:26:32Z
dc.date.issued2021
dc.date.updated2022-05-29T08:17:00Z
dc.description.abstractKingdom of Tonga in Polynesia is one of the most obese nations where metabolic conditions, sedentary lifestyles, and poor quality diet are widespread. These factors can lead to poor musculoskeletal health. However, whether metabolic abnormalities such as osteoporosis occurred in archaeological populations of Tonga is unknown. We employed a microscopic investigation of femur samples to establish whether bone loss afflicted humans in this Pacific region approximately 3000 years ago. Histology, laser confocal microscopy, and synchrotron Fourier-transform infrared microspectroscopy were used to measure bone vascular canal densities, bone porosity, and carbonate and phosphate content of bone composition in eight samples extracted from adult Talasiu males and females dated to 2650 BP. Compared to males, samples from females had fewer vascular canals, lower carbonate and phosphate content, and higher bone porosity. Although both sexes showed evidence of trabecularised cortical bone, it was more widespread in females (35.5%) than males (15.8%). Our data suggest experiences of advanced bone resorption, possibly as a result of osteoporosis. This provides first evidence for microscopic bone loss in a sample of archaeological humans from a Pacific population widely afflicted by metabolic conditions today.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2045-2322en_AU
dc.identifier.urihttp://hdl.handle.net/1885/294552
dc.language.isoen_AUen_AU
dc.provenanceTis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_AU
dc.publisherNature Publishing Groupen_AU
dc.rights© The Author(s) 2021en_AU
dc.sourceScientific Reportsen_AU
dc.titleBone loss markers in the earliest Pacific Islandersen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue1en_AU
local.bibliographicCitation.lastpage16en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationMiszkiewicz, Justyna, College of Arts and Social Sciences, ANUen_AU
local.contributor.affiliationValentin, Frederique, CNRSen_AU
local.contributor.affiliationVrahnas, Christina, University of Dundeeen_AU
local.contributor.affiliationSims, Natalie, University of Melbourneen_AU
local.contributor.affiliationVongsvivut, Jitraporn, ANSTO – Australian Synchrotronen_AU
local.contributor.affiliationTobin, Mark, Australian Synchrotronen_AU
local.contributor.affiliationClark, Geoffrey, College of Asia and the Pacific, ANUen_AU
local.contributor.authoremailu9510963@anu.edu.auen_AU
local.contributor.authoruidMiszkiewicz, Justyna, u1021221en_AU
local.contributor.authoruidClark, Geoffrey, u9510963en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor430101 - Archaeological scienceen_AU
local.identifier.absfor320801 - Cell physiologyen_AU
local.identifier.absseo211101 - Pacific Peoples determinants of healthen_AU
local.identifier.absseo200411 - Overweight and obesityen_AU
local.identifier.absseo280113 - Expanding knowledge in history, heritage and archaeologyen_AU
local.identifier.ariespublicationa383154xPUB17583en_AU
local.identifier.citationvolume11en_AU
local.identifier.doi10.1038/s41598-021-83264-3en_AU
local.identifier.scopusID2-s2.0-85101100022
local.identifier.thomsonIDWOS:000621344600006
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://www.nature.com/articles/s41598-021-83264-3en_AU
local.type.statusPublished Versionen_AU

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