Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor associated kinase 4
Date
Authors
Enders, Anselm
Pannicke, Ulrich
Berner, Reihnard
Henneke, Phillip
Radlinger, Klaus
Schwarz, Klaus
Ehl, Stephan
Journal Title
Journal ISSN
Volume Title
Publisher
Mosby Inc
Abstract
We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.
Description
Citation
Collections
Source
Journal of Pediatrics
Type
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31
Downloads
File
Description