Sequelae of multidrug-resistant tuberculosis: protocol for a systematic review and meta-analysis
Date
2018
Authors
Alene, Kefyalew Addis
Clements, Archie
McBryde, Emma
Jaramillo, Ernesto
Lonnroth, Knut
Shaweno, Debebe
Viney, Kerri
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BMJ Publishing Group
Abstract
Introduction The sequelae of multidrug-resistant tuberculosis (MDR-TB) are poorly understood and inconsistently reported. We will aim to assess the existing evidence for the clinical, psychological, social and economic sequelae of MDR-TB and to assess the health-related quality of life in patients with MDR-TB.
Methods and analysis We will perform a systematic review and meta-analysis of published studies reporting sequelae of MDR-TB. We will search PubMed, SCOPUS, ProQuest, Web of Science and PsychINFO databases up to 5 September 2017. MDR-TB sequelae will include any clinical, psychological, social and economic effects as well as health-related quality of life that occur after MDR-TB treatment or illness. Two researchers will screen the titles and abstracts of all citations identified in our search, extract data, and assess the scientific quality using standardised formats. Providing there is appropriate comparability in the studies, we will use a random-effects meta-analysis model to produce pooled estimates of MDR-TB sequelae from the included studies. We will stratify the analyses based on treatment regimen, comorbidities (such as HIV status and diabetes mellitus), previous TB treatment history and study setting.
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BMJ Open
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Journal article
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Open Access
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Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license
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