PfCRT and its role in antimalarial drug resistance

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dc.contributor.authorEcker, Andrea
dc.contributor.authorLehane, Adele
dc.contributor.authorClain, Jerome
dc.contributor.authorFidock, David A
dc.date.accessioned2015-12-07T22:19:04Z
dc.date.issued2012
dc.date.updated2016-02-24T10:26:24Z
dc.description.abstractPlasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT). These mutations impart upon PfCRT the ability to efflux chloroquine from
dc.identifier.issn1471-4922
dc.identifier.urihttp://hdl.handle.net/1885/19146
dc.publisherElsevier
dc.sourceTrends in Parasitology
dc.subjectKeywords: artemisinin; chloroquine; antimalarial drug resistance; cell culture; Dictyostelium discoideum; drug mechanism; epistasis; gametocyte; genetic association; haplotype; host susceptibility; human; multidrug resistance; mutant; mutation; nonhuman; parasite t Drug resistance; Haplotypes; Heme detoxification; Malaria; PfCRT; Plasmodium falciparum; Selective sweep; Transmission
dc.titlePfCRT and its role in antimalarial drug resistance
dc.typeJournal article
local.bibliographicCitation.issue11
local.bibliographicCitation.lastpage514
local.bibliographicCitation.startpage504
local.contributor.affiliationEcker, Andrea, Department of Microbiology and Immunology, College of Physicians and Surgeons
local.contributor.affiliationLehane, Adele, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationClain, Jerome, College of Physicians and Surgeons, Columbia University
local.contributor.affiliationFidock, David A, Columbia University Medical Center
local.contributor.authoruidLehane, Adele, u3356728
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060502 - Infectious Agents
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.absseo920109 - Infectious Diseases
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu4008405xPUB7
local.identifier.citationvolume28
local.identifier.doi10.1016/j.pt.2012.08.002
local.identifier.scopusID2-s2.0-84867843026
local.identifier.thomsonID000310939800008
local.type.statusPublished Version

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