PfCRT and its role in antimalarial drug resistance

Date

Authors

Ecker, Andrea

Lehane, Adele

Clain, Jerome

Fidock, David A

Publisher

Elsevier

Abstract

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT). These mutations impart upon PfCRT the ability to efflux chloroquine from

Keywords

Keywords: artemisinin; chloroquine; antimalarial drug resistance; cell culture; Dictyostelium discoideum; drug mechanism; epistasis; gametocyte; genetic association; haplotype; host susceptibility; human; multidrug resistance; mutant; mutation; nonhuman; parasite t Drug resistance; Haplotypes; Heme detoxification; Malaria; PfCRT; Plasmodium falciparum; Selective sweep; Transmission

URI

http://hdl.handle.net/1885/19146

Collections

ANU Research Publications

Source

Trends in Parasitology

Type

Journal article

DOI

10.1016/j.pt.2012.08.002

Restricted until

2037-12-31

Downloads

File

Description

01_Ecker_PfCRT_and_its_role_in_2012.pdf (791.21 KB)