Approaches to the neurotrophically active natural product 11-O-debenzoyltashironin: a chemoenzymatic total synthesis of the structurally related sesquiterpene khusiol

Abstract

Soothes your nerves: The enantiomerically enriched cis-1,2-dihydrocatechol 4 has been converted, over 16 steps including one involving an intramolecular Diels-Alder reaction, into the sesquiterpenoid natural product khusiol (3), which is structurally related to the neurite outgrowth-promoting natural product 11-O-debenzoyltashironin (1). Show more