C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties

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dc.contributor.authorBanwell, Martinen_AU
dc.contributor.authorBezos, Annaen_AU
dc.contributor.authorBurns, Christopheren_AU
dc.contributor.authorKruszelnicki, Irmaen_AU
dc.contributor.authorSu, Stephenen_AU
dc.contributor.authorSydnes, Magneen_AU
dc.contributor.authorParish, Christopheren_AU
dc.date.accessioned2015-12-13T22:35:28Z
dc.date.issued2006
dc.date.updated2015-12-11T09:27:58Z
dc.description.abstractFour enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/1885/76590
dc.publisherPergamon-Elsevier Ltd
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectKeywords: alkaloid derivative; angiogenesis inhibitor; cryptopleurine; cryptopleurine derivative; julandine derivative; pi 88; quinolizidine derivative; unclassified drug; animal cell; animal tissue; antiangiogenic activity; article; controlled study; cytotoxicity; Anti-angiogenic; cis-Stilbene; Combretastatin A4; Phenanthroquinolizidine
dc.titleC8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties
dc.typeJournal article
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpage185
local.bibliographicCitation.startpage181
local.contributor.affiliationBanwell, Martin, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBezos, Anna, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBurns, Christopher, Cytopia Pty Ltd
local.contributor.affiliationKruszelnicki, Irma, Cytopia Pty Ltd
local.contributor.affiliationParish, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSu, Stephen, Cytopia Pty Ltd
local.contributor.affiliationSydnes, Magne, College of Physical and Mathematical Sciences, ANU
local.contributor.authoruidBanwell, Martin, u9500594
local.contributor.authoruidBezos, Anna, u9107121
local.contributor.authoruidParish, Christopher, u6900322
local.contributor.authoruidSydnes, Magne, u4029423
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationMigratedxPub5403
local.identifier.citationvolume16
local.identifier.doi10.1016/j.bmcl.2005.09.032
local.identifier.scopusID2-s2.0-27744523400
local.type.statusPublished Version

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