Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)
Date
2012
Authors
Gandhi, Neha S
Freeman, Craig
Mancera, Ricardo L
Parish, Christopher
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
Mammalian heparanase is an endo-glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparan
Description
Keywords
Keywords: angiogenesis inhibitor; antineoplastic agent; beta glucuronidase; carbohydrate; glucosamine; glucuronic acid; glycosaminoglycan; glycosaminoglycan polysulfate; heparan sulfate; heparanase; heparin derivative; indole; morpholine; pi 88; piperidine; pyridin glycol-split; glycosidase; heparanase; heparin; molecular dynamics
Citation
Collections
Source
Glycobiology
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31
Downloads
File
Description