Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)

Gandhi, Neha S; Freeman, Craig; Mancera, Ricardo L; Parish, Christopher

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase)

Date

2012

Authors

Gandhi, Neha S

Freeman, Craig

Mancera, Ricardo L

Parish, Christopher

Publisher

Oxford University Press

Abstract

Mammalian heparanase is an endo-glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparan