Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center

Date

2017

Authors

Yan, Hu
Wu, Longyan
Shih, Changming
Hou, Shiyue
Shi, Jingwen
Mao, Tianyang
Chen, Wenbin
Balakishnan, Bhavani
Chen, Yingjia
Jiang, Haochen

Journal Title

Journal ISSN

Volume Title

Publisher

Cell Press

Abstract

Follicular T helper (TFH) cells orchestrate the germinal center (GC) response locally. TFH localization in GCs is controlled by chemo-guidance cues and antigen-specific adhesion. Here. we define an antigen-independent, contact-dependent, adhesive guidance system for TFH cells. Unusual for amoeboid cell migration, the system is composed of transmembrane plexin B2 (PlxnB2) molecule, which is highly expressed by GC B cells, and its transmembrane binding partner semaphorin 4C (Sema4C), which is upregulated on TFH cells. Sema4C on TFH cells serves as a receptor to sense the GC-presented PlxnB2 cue and biases TFH migration inwards at the GC edge to promote GC access. The absence of PlxnB2 from the GC or Sema4C from TFH cells causes TFH accumulation along the GC border, impairs T-B cell interactions in the GC, and is associated with defective plasma cell production and affinity maturation. Therefore, Sema4C and PlxnB2 regulate GC TFH recruitment and function and optimize antibody responses.

Description

Keywords

Citation

Source

Cell Reports

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

Creative Commons Attribution Non-Commercial No Derivatives 4.0 International

DOI

10.1016/j.celrep.2017.04.022

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