Roles of Notch and NF-kB signaling in allogeneic responses

Date

2006

Authors

Murase, Tosei

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Abstract

The induction of robust allograft tolerance is the ultimate goal for clinical transplantation. Although studies have identified that dendritic cells (DCs) are important for induction of antigen-specific tolerance, the requirements for generating tolerogenic DCs are yet to be elucidated. Recently, it has been demonstrated the modulation of two signaling pathways, Notch and nuclear factor KB (NF-KB) can render DCs tolerogenic. The studies documented here examine (1) whether immature DCs over-expressing Notch-related molecules (Jagged-I, Delta-like-I (Dll-I), Lunatic Fringe (Ung) , and Manic Fringe (Mfng)) act as immunoregulatory DCs and promote allograft survival; and (2) whether DCs deficient in NF-KB signaling inhibit the alloreactive T cell response and promote allograft survival ... Although the potential for Notch signaling to promote alloantigen-specific tolerance remains unresolved, these studies suggest that inhibition of NF-KB signaling in DCs represent a potential approach for promoting allograft survival.

Description

Keywords

Transplantation, Notch, NF-kB, allogeneic response, dendritic cells, BAY11-7082

Citation

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Type

Thesis (PhD)

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DOI

10.25911/5d7a27c0c1d62

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