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Does the cerebral cortex exacerbate dopaminergic cell death in the substantia nigra of 6OHDA-lesioned rats?

Date

Authors

Luquin, Natasha

Mitrofanis, John

Publisher

Elsevier

Abstract

We have explored the survival of dopaminergic cells of the substantia nigra pars compacta (SNc) in 6 hydroxydopamine (6OHDA)-lesioned rats with prior cortical removal. There were ∼35% more dopaminergic cells in the ventral sector of SNc (vSNc) of 6OHDA-

Keywords

Keywords: oxidopamine; animal experiment; animal model; animal tissue; article; brain cortex; brain protection; cell count; cell structure; cell survival; controlled study; dopaminergic nerve cell; excitotoxicity; male; nerve cell necrosis; nonhuman; Parkinson dise Basal ganglia; Cell death; Cortical removal; Glutamate excitotoxicity; Neuroprotection; Parkinson disease

URI

http://hdl.handle.net/1885/27145

Collections

ANU Research Publications

Source

Parkinsonism and Related Disorders

Type

Journal article

DOI

10.1016/j.parkreldis.2007.08.010

Restricted until

2037-12-31

Downloads

File

Description

01_Luquin_Does_the_cerebral_cortex_2008.pdf (952.58 KB)