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FITC-Functionalized TiO2 Nanoparticles for Simultaneous Neuron Imaging and in Cell Photocatalysis

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Date

2014

Authors

Zhang, Tina
Go, Mary Ann
Stricker, Christian
Daria, Vincent
Tricoli, Antonio

Journal Title

Journal ISSN

Volume Title

Publisher

Materials Research Society

Abstract

Crystalline TiO₂ nanoparticles were produced by scalable flame spray pyrolysis of organometallic solutions. A protocol is presented for the optimized functionalization of these particles with fluorescein isothiocyanate (FITC), an important biomedical dye via a lysine linker. The pH, stoichiometry and time for lysine reaction were determined for highest dye loading and minimized degree of polylysine formation. Acidic reaction conditions, low lysine concentration and short reaction times were found to meet this aim. The resulting particles were used for imaging single neurons, showing high fluorescence emission and ability for the particles to diffuse into small neuron structures such as dendrites.

Description

Keywords

catalytic, composite, flame synthesis

Citation

URI

http://hdl.handle.net/1885/101038

Collections

ANU Research Publications

Source

MRS Proceedings

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1557/opl.2014.893

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