Dopamine D2 receptor gene polymorphisms in newborn infants of drug-using women

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dc.contributor.authorOei, Ju Lee
dc.contributor.authorXu, H. X.
dc.contributor.authorABDEL-LATIF, Mohamed E.
dc.contributor.authorVunnam, K.
dc.contributor.authorAl-Amry, A.
dc.contributor.authorClews, S.
dc.contributor.authorFalconer, J.
dc.contributor.authorFeller, J. M.
dc.contributor.authorLui, K.
dc.date.accessioned2016-03-29T05:25:39Z
dc.date.available2016-03-29T05:25:39Z
dc.date.issued2011
dc.date.updated2016-06-14T08:35:28Z
dc.description.abstractOBJECTIVES To determine the characteristics of dopamine D2 receptor gene (DRD2) polymorphisms in drug-exposed and unexposed neonates and the relationship to neonatal abstinence syndrome (NAS). DESIGN Retrospective case-control analysis between drug-exposed and unexposed infants between DRD2 polymorphisms, drug exposure and NAS treatment. PATIENTS Drug-exposed (n=48) and drug-free (n=49) infants born between March 1999 and December 2006. METHODS Analysis of DNA for the Taq1A, -141Ins/Del and Ser311Cys DRD2 polymorphisms. Drug exposure was determined by antenatal maternal drug and alcohol history. Frequency measures of DRD2 polymorphisms were compared between drug-exposed infants, treatment NAS medication and with control infants. SETTING Tertiary maternity hospital, Sydney, Australia. MAIN OUTCOME MEASURES All infants were born in a good condition (25.7% <37 weeks gestation). Opiates (methadone and heroin) were used by 45 (93.8%) of drug-exposed mothers. The A2A2 allele was more common in drug-exposed infants (37 (77.0%) versus 23 (46.9%), p=0.003) but the A1A2 allele was more common in control infants (23 (46.9%) versus 4 (8.3%), p=0.00002). The-ins allele was more common in control (39 (79.6%) versus 20 (41.7%), p=<0.01) and unmedicated drug-exposed (14/25 (56%) versus 5/23 (21.7%), p=0.02) infants. The majority of infants (41 (83.7%) controls versus 41 (85.4%), p=1.000) expressed the least common, Ser polymorphism. CONCLUSIONS DRD2 polymorphisms are detectable from DNA obtained from stored blood spots. The -ins allele is more common in control and unmedicated drug-exposed infants. Further study is recommended to explore postneonatal outcomes especially in relation to neuropsychiatric behaviours.
dc.description.sponsorshipThis study was supported by the Cornucopia Foundation and the Royal Hospital for Women Foundation and by funding from the Leslie Stevens Fund for Newborn Research, The Cornucopia Foundation and The Royal Hospital for Women Foundation.en_AU
dc.identifier.issn1359-2998en_AU
dc.identifier.urihttp://hdl.handle.net/1885/100905
dc.publisherBMJ Publishing Group
dc.rights© BMJ Publishing Group
dc.sourceArchives of Disease in Childhood - Fetal and Neonatal Edition
dc.subjectalleles
dc.subjectblood specimen collection
dc.subjectcase-control studies
dc.subjectdna
dc.subjectfemale
dc.subjectgenetic predisposition to disease
dc.subjectgenotype
dc.subjecthumans
dc.subjectinfant, newborn
dc.subjectmale
dc.subjectneonatal abstinence syndrome
dc.subjectpregnancy
dc.subjectpregnancy complications
dc.subjectprognosis
dc.subjectreceptors, dopamine d2
dc.subjectopioid-related disorders
dc.subjectpolymorphism, genetic
dc.titleDopamine D2 receptor gene polymorphisms in newborn infants of drug-using women
dc.typeJournal article
local.bibliographicCitation.issue3en_AU
local.bibliographicCitation.lastpageF198en_AU
local.bibliographicCitation.startpageF193en_AU
local.contributor.affiliationOei, J, University of New South Wales, Australiaen_AU
local.contributor.affiliationXu, Hong Xiu, The Royal Hospital for Women, Australiaen_AU
local.contributor.affiliationMohamed, Abdel-Latif, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National Universityen_AU
local.contributor.affiliationVunnam, Krishna, The Royal Hospital for Women, Australiaen_AU
local.contributor.affiliationAl-Amry, Adil, The Royal Hospital for Women, Australiaen_AU
local.contributor.affiliationClews, Sara, The Langton Centre, Australiaen_AU
local.contributor.affiliationFalconer, Janet, The Langton Centre, Australiaen_AU
local.contributor.affiliationFeller, John M, Sydney Children's Hospital, Australiaen_AU
local.contributor.affiliationLui, Kei, Royal Hospital for Women, Australiaen_AU
local.contributor.authoremailabdel-latif.mohamed@act.gov.auen_AU
local.contributor.authoruidu4981243en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor110303en_AU
local.identifier.ariespublicationf5625xPUB1543en_AU
local.identifier.citationvolume97en_AU
local.identifier.doi10.1136/archdischild-2011-300235en_AU
local.identifier.essn1468-2052en_AU
local.identifier.scopusID2-s2.0-84860840771
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttp://www.bmj.com/company/en_AU
local.type.statusMetadata onlyen_AU

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