5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells

McKenzie, S. M.; Doe, W. F.; Buffinton, G. D.

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5-Aminosalicylic acid prevents oxidant mediated damage of glyceraldehyde-3-phosphate dehydrogenase in colon epithelial cells

Date

1999

Authors

McKenzie, S. M.

Doe, W. F.

Buffinton, G. D.

Publisher

BMJ Publishing Group

Abstract

Background—Reactive oxygen and nitrogen derived species produced by activated neutrophils have been implicated in the damage of mucosal proteins including the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in the active inflammatory lesion in patients with in-flammatory bowel disease (IBD). This study investigated the eYcacy of currently used IBD therapeutics to prevent injury mediated by reactive oxygen and nitrogen derived species.