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Macromolecular modeling and design in Rosetta: recent methods and frameworks

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Date

2020-06-01

Authors

Koehler Leman, Julia
Weitzner, Brian D.
Lewis, Steven M.
Adolf-Bryfogle, Jared
Alam, Nawsad
Alford, Rebecca F.
Aprahamian, Melanie
Baker, David
Barlow, Kyle A.
Barth, Patrick

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/268859

Collections

ANU Research Publications

Source

Nature Methods: techniques for life scientists and chemists

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/s41592-020-0848-2

Restricted until

2099-12-31

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Description
s41592-020-0848-2.pdf (2.52 MB)

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