Macromolecular modeling and design in Rosetta: recent methods and frameworks
Date
2020-06-01
Authors
Koehler Leman, Julia
Weitzner, Brian D.
Lewis, Steven M.
Adolf-Bryfogle, Jared
Alam, Nawsad
Alford, Rebecca F.
Aprahamian, Melanie
Baker, David
Barlow, Kyle A.
Barth, Patrick
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Nature Publishing Group
Abstract
The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability.
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Nature Methods: techniques for life scientists and chemists
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Journal article
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Restricted until
2099-12-31
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