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Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

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Date

2012

Authors

Velez, Jorge I.
Chandrasekharappa, Settara C.
Henao, E.
Martinez, Ariel F.
Harper, U.
Jones, Marypat
Solomon, Benjamin D.
Lopez, L.
Garcia, Gloria
Aguirre-Acevedo, D. C.

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheim

Description

Keywords

Keywords: protein; PSEN1 protein; unclassified drug; age; Alzheimer disease; article; bootstrapping; cohort analysis; disease severity; DNA extraction; gene frequency; gene locus; gene mutation; genetic association; human; priority journal; single nucleotide polymo Alzheimer's disease; bootstrap; DNA pooling; GWAS; modifiers; PSEN1

Citation

URI

http://hdl.handle.net/1885/20412

Collections

ANU Research Publications

Source

Molecular Psychiatry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/mp.2012.81

Restricted until

2037-12-31

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01_Velez_Pooling/bootstrap-based_GWAS_2012.pdf (507.81 KB)

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