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The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin β1

Date

Authors

Forwood, Jade

Harding, Ruth E

Jans, David A

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

The sex-determining factor SRY is a DNA-binding protein that diverts primordial gonads from the ovarian pathway toward male differentiation to form testes. It gains access to the nucleus through two distinct nuclear localization signals (NLSs) that flank

Keywords

Keywords: Antibodies; Bioassay; Biological organs; DNA; Electrophoresis; Enzymes; Polarization; Nuclear imports; Sex-determining factors; Biotechnology; DNA binding protein; guanosine diphosphate; guanosine triphosphate; high mobility group B1 protein; high mobilit

URI

http://hdl.handle.net/1885/92898

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

DOI

10.1074/jbc.M101668200

Restricted until

2037-12-31

Downloads

File

Description

01_Forwood_The_C-terminal_nuclear_2001.pdf (894.23 KB)