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Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

Date

2014

Authors

Summers, Robert
Dave, Anurag
Dolstra, Tegan
Bellanca, Sebastiano
Marchetti, Rosa
Nash, Megan
Richards, Sashika
Goh, Xin-Lin
Schenk, Robyn
Stein, Wilfred D.

Journal Title

Journal ISSN

Volume Title

Publisher

National Academy of Sciences (USA)

Abstract

Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given

Description

Keywords

Citation

Source

National Academy of Sciences. Proceedings

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1073/pnas.1322965111

Restricted until