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Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre

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Date

2016-12

Authors

Lea-Henry, Tom N
Jiang, Simon H

Journal Title

Journal ISSN

Volume Title

Publisher

AME Publishing Company

Abstract

Yamamoto et al. have studied T follicular helper (TFH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of TFH, reproducing infection-associated TFH accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate TFHIL4 and CD154 expression with superior antibody responses. Accumulation of TFH was accompanied by aberrant expression of non-TFH transcriptional regulators such as BLIMP1 in TFH, suggesting viral induced abnormalities may affect TFH function.

Description

Keywords

T follicular helper cells, antibody, germinal centre (gc), human immunodeficiency virus (hiv), simian immunodeficiency virus (siv)

Citation

URI

http://hdl.handle.net/1885/113756

Collections

ANU Research Publications

Source

Annals of translational medicine

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.21037/atm.2016.11.76

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