Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands

Smith, N M; Labrunie, Gaelle; Corry, Ben; Tran, Phong Lan Thao; Norret, Marck; Djavaheri-Mergny, Mojgan; Raston, Colin Llewellyn; Mergny, Jean-Louis

Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands

Date

2011

Authors

Smith, N M

Labrunie, Gaelle

Corry, Ben

Tran, Phong Lan Thao

Norret, Marck

Djavaheri-Mergny, Mojgan

Raston, Colin Llewellyn

Mergny, Jean-Louis

Publisher

Royal Society of Chemistry

Abstract

A series of novel 2,4,6-triarylpyridines have been synthesized and their interactions with intramolecular G-quadruplexes have been measured by Förster Resonance Energy Transfer (FRET) melting and Fluorescent Intercalator Displacement (FID) assays. A few