Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

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dc.contributor.authorKhalilpour, Saba
dc.contributor.authorBehnammanesh, Ghazaleh
dc.contributor.authorSuede, Fouad
dc.contributor.authorEzzat, Mohammed Oday
dc.contributor.authorMuniandy, Jayadhisan
dc.contributor.authorTabana, Yasser
dc.contributor.authorAhamed, Mohamed B. Khadeer
dc.contributor.authorTamayol, Ali
dc.contributor.authorAbdul Majid, Amin Malik Shah Bin
dc.contributor.authorSangiovanni, Enrico
dc.contributor.authorDell'Agli, Mario
dc.contributor.authorAbdul Majid, Aman Shah
dc.date.accessioned2019-04-19T12:22:06Z
dc.date.available2019-04-19T12:22:06Z
dc.date.issued2018
dc.date.updated2019-03-12T07:31:45Z
dc.description.abstractModulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2227-9059en_AU
dc.identifier.urihttp://hdl.handle.net/1885/160494
dc.language.isoen_AUen_AU
dc.publisherM D P I AGen_AU
dc.rights© 2018 by the authorsen_AU
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceBiomedicinesen_AU
dc.titleNeuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathyen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue2en_AU
local.contributor.affiliationKhalilpour, Saba, Universita degli Studi di Milanoen_AU
local.contributor.affiliationBehnammanesh, Ghazaleh, University of Missourien_AU
local.contributor.affiliationSuede, Fouad, University of Science Malaysiaen_AU
local.contributor.affiliationEzzat, Mohammed Oday, Universti Sains Malaysiaen_AU
local.contributor.affiliationMuniandy, Jayadhisan, University of Science Malaysiaen_AU
local.contributor.affiliationTabana, Yasser, University of Science Malaysiaen_AU
local.contributor.affiliationAhamed, Mohamed B. Khadeer, Universiti Sains Malaysiaen_AU
local.contributor.affiliationTamayol, Ali, University of Nebraska-Lincolnen_AU
local.contributor.affiliationAbdul Majid, Amin Malik Shah Bin, College of Health and Medicine, ANUen_AU
local.contributor.affiliationSangiovanni, Enrico, Universita degli Studi di Milanoen_AU
local.contributor.affiliationDell'Agli, Mario, Universita degli Studi di Milanoen_AU
local.contributor.affiliationAbdul Majid, Aman Shah, Quest International Universityen_AU
local.contributor.authoremailrepository.admin@anu.edu.auen_AU
local.contributor.authoruidAbdul Majid, Amin Malik Shah Bin, u1026638en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111502 - Clinical Pharmacology and Therapeuticsen_AU
local.identifier.absseo860803 - Human Pharmaceutical Treatments (e.g. Antibiotics)en_AU
local.identifier.ariespublicationu4485658xPUB1935en_AU
local.identifier.citationvolume6en_AU
local.identifier.doi10.3390/biomedicines6020048en_AU
local.identifier.scopusID2-s2.0-85050315614
local.identifier.thomsonID000436489000012
local.identifier.uidSubmittedByu4485658en_AU
local.type.statusPublished Versionen_AU

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