Urinary alkalinisation for acute chlorophenoxy herbicide poisoning

dc.contributor.authorRoberts, Darren
dc.contributor.authorBuckley, Nicholas
dc.date.accessioned2015-12-10T22:51:14Z
dc.date.issued2007
dc.date.updated2015-12-10T07:24:05Z
dc.description.abstractBackground: Acute poisoning with chlorophenoxy herbicides (such as 2,4-D, MCPA, 2,4,5-T and mecoprop) is reported worldwide, potentially causing severe toxicity and death in exposed patients. Animal studies support the application of urinary alkalinisation (particularly using sodium bicarbonate) in the management of acute chlorophenoxy herbicide poisoning to facilitate excretion of these herbicides. Some case reports of human exposure have suggested benefit from urinary alkalinisation also. Objectives: To assess the efficacy of urinary alkalinisation, in particular sodium bicarbonate, for the treatment of acute chlorophenoxy herbicide poisoning. Search strategy: We searched MEDLINE, EMBASE, CENTRAL, Current Awareness in Clinical Toxicology, Info Trac, http://www.google.com.au, and Science Citation Index of studies identified by the previous searches. The bibliographies of identified articles were reviewed and experts in the field were contacted. Selection criteria: Randomised controlled trials of urinary alkalinisation in patients ingesting a chlorophenoxy herbicide and presenting within 24 to 48 hours of poisoning were sought. The quality of studies and eligibility for inclusion was assessed using criteria by Jadad and Schulz. Data collection and analysis: Authors independently extracted data from the identified studies using a pre-designed form. Study design, including the method of randomisation, participant characteristics, type of intervention and outcomes were all recorded. Main results: No studies were identified which satisfied inclusion criteria. Authors' conclusions: There is insufficient evidence to support the routine use of urinary alkalinisation for acute chlorophenoxy herbicide poisoning. A well conducted randomised controlled trial is urgently required to determine whether the efficacy and indications of this treatment.
dc.identifier.issn1469-493X
dc.identifier.urihttp://hdl.handle.net/1885/58956
dc.publisherThe Cochrane Library
dc.sourceCochrane Database of Systematic Reviews (CDSR)
dc.subjectKeywords: 2 (4 chloro 2 methylphenoxy)acetic acid; 2,4 dichlorophenoxyacetic acid; 2,4,5 trichlorophenoxyacetic acid; bicarbonate; herbicide; mecoprop; alkalinization; clinical trial; human; intoxication; kidney clearance; mortality; review; systematic review; trea 2,4-dichlorophenoxyacetic acid [poisoning]; 2-methyl-4-chlorophenoxyacetic acid [poisoning]; Alkalies [therapeutic use]; Herbicides [*poisoning]; Humans; Poisoning [therapy; urine]
dc.titleUrinary alkalinisation for acute chlorophenoxy herbicide poisoning
dc.typeJournal article
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpage10
local.bibliographicCitation.startpage1
local.contributor.affiliationRoberts, Darren, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBuckley, Nicholas, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4070191@anu.edu.au
local.contributor.authoruidRoberts, Darren, u4070191
local.contributor.authoruidBuckley, Nicholas, a150111
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111799 - Public Health and Health Services not elsewhere classified
local.identifier.ariespublicationu4167262xPUB466
local.identifier.citationvolumeArt. No.: CD005488.
local.identifier.doi10.1002/14651858.CD005488.pub2
local.identifier.scopusID2-s2.0-35148867089
local.identifier.uidSubmittedByu4167262
local.type.statusPublished Version

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