How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids

Date

2011

Authors

Whitworth, Judith
Ong, Lee Lin (Sharon)

Journal Title

Journal ISSN

Volume Title

Publisher

W B Saunders Co

Abstract

The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.

Description

Keywords

Keywords: acetylcysteine; acetylsalicylic acid; angiotensin II; apocynin; arginine; argipressin; atenolol; atorvastatin; corticotropin; dexamethasone; endothelin; felodipine; folic acid; glucocorticoid; guanosine triphosphate cyclohydrolase I; hydrocortisone; icosa 20-hydroxyeicosatetranoic acid; Glucocorticoid; Hypertension; Nitric oxide; Oxidative stress; Prostanoids

Citation

Source

Endocrinology and Metabolism Clinics of North America

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.ecl.2011.01.010

Restricted until

2037-12-31