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How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids

Date

Authors

Whitworth, Judith

Ong, Lee Lin (Sharon)

Publisher

W B Saunders Co

Abstract

The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.

Keywords

Keywords: acetylcysteine; acetylsalicylic acid; angiotensin II; apocynin; arginine; argipressin; atenolol; atorvastatin; corticotropin; dexamethasone; endothelin; felodipine; folic acid; glucocorticoid; guanosine triphosphate cyclohydrolase I; hydrocortisone; icosa 20-hydroxyeicosatetranoic acid; Glucocorticoid; Hypertension; Nitric oxide; Oxidative stress; Prostanoids

URI

http://hdl.handle.net/1885/69884

Collections

ANU Research Publications

Source

Endocrinology and Metabolism Clinics of North America

Type

Journal article

DOI

10.1016/j.ecl.2011.01.010

Restricted until

2037-12-31

Downloads

File

Description

01_Whitworth_How_do_glucocorticoids_cause_2011.pdf (169.63 KB)