Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi

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dc.contributor.authorChooi, Yit-Heng
dc.contributor.authorFang, Jinxu
dc.contributor.authorLiu, Hong
dc.contributor.authorFiller, Scott G
dc.contributor.authorWang, Pin
dc.contributor.authorTang, Yi
dc.date.accessioned2015-12-13T22:49:13Z
dc.date.issued2013
dc.date.updated2016-02-24T09:43:28Z
dc.description.abstractActivation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
dc.identifier.issn1523-7060
dc.identifier.urihttp://hdl.handle.net/1885/80435
dc.publisherAmerican Chemical Society
dc.sourceOrganic Letters
dc.subjectKeywords: dimethylallyltransferase; immunosuppressive agent; polyketide; animal; article; Aspergillus fumigatus; chemistry; conformation; drug effect; enzymology; fungus; genetics; genome; HeLa cell; human; isolation and purification; macrophage; metabolism; mouse;
dc.titleGenome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage783
local.bibliographicCitation.startpage780
local.contributor.affiliationChooi, Yit-Heng, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFang, Jinxu, University of Southern California
local.contributor.affiliationLiu, Hong, University of Southern California
local.contributor.affiliationFiller, Scott G, University of California
local.contributor.affiliationWang, Pin, University of Southern California
local.contributor.affiliationTang, Yi, University of California
local.contributor.authoruidChooi, Yit-Heng, u5418153
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030502 - Natural Products Chemistry
local.identifier.absfor060113 - Synthetic Biology
local.identifier.absfor060704 - Plant Pathology
local.identifier.ariespublicationf5625xPUB8698
local.identifier.citationvolume15
local.identifier.doi10.1021/ol303435y
local.identifier.scopusID2-s2.0-84873943666
local.identifier.thomsonID000315254500016
local.type.statusPublished Version

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